Viral polymerase inhibitors T-705 and T-1105 are potential inhibitors of Zika virus replication

Since 2015, 69 countries and territories have reported evidence of vector-borne Zika virus (ZIKV) transmission. Currently, there are no effective licensed vaccines or drugs available for the treatment or prevention of ZIKV infection. We tested a series of compounds for their ability to inhibit ZIKV...

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Autores principales: Cai, Lei, Sun, Yajie, Song, Yabin, Xu, Likun, Bei, Zhuchun, Zhang, Dongna, Dou, Yuanyuan, Wang, Hongquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2017
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563514/
https://www.ncbi.nlm.nih.gov/pubmed/28597088
http://dx.doi.org/10.1007/s00705-017-3436-8
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author Cai, Lei
Sun, Yajie
Song, Yabin
Xu, Likun
Bei, Zhuchun
Zhang, Dongna
Dou, Yuanyuan
Wang, Hongquan
author_facet Cai, Lei
Sun, Yajie
Song, Yabin
Xu, Likun
Bei, Zhuchun
Zhang, Dongna
Dou, Yuanyuan
Wang, Hongquan
author_sort Cai, Lei
collection PubMed
description Since 2015, 69 countries and territories have reported evidence of vector-borne Zika virus (ZIKV) transmission. Currently, there are no effective licensed vaccines or drugs available for the treatment or prevention of ZIKV infection. We tested a series of compounds for their ability to inhibit ZIKV replication in cell culture. The compounds in T-705 (favipiravir) and T-1105 were found to have antiviral activity, suggesting that these compounds are promising candidates for further development as specific antiviral drugs against ZIKV. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00705-017-3436-8) contains supplementary material, which is available to authorized users.
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spelling pubmed-55635142017-09-05 Viral polymerase inhibitors T-705 and T-1105 are potential inhibitors of Zika virus replication Cai, Lei Sun, Yajie Song, Yabin Xu, Likun Bei, Zhuchun Zhang, Dongna Dou, Yuanyuan Wang, Hongquan Arch Virol Brief Report Since 2015, 69 countries and territories have reported evidence of vector-borne Zika virus (ZIKV) transmission. Currently, there are no effective licensed vaccines or drugs available for the treatment or prevention of ZIKV infection. We tested a series of compounds for their ability to inhibit ZIKV replication in cell culture. The compounds in T-705 (favipiravir) and T-1105 were found to have antiviral activity, suggesting that these compounds are promising candidates for further development as specific antiviral drugs against ZIKV. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00705-017-3436-8) contains supplementary material, which is available to authorized users. Springer Vienna 2017-06-08 2017 /pmc/articles/PMC5563514/ /pubmed/28597088 http://dx.doi.org/10.1007/s00705-017-3436-8 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Brief Report
Cai, Lei
Sun, Yajie
Song, Yabin
Xu, Likun
Bei, Zhuchun
Zhang, Dongna
Dou, Yuanyuan
Wang, Hongquan
Viral polymerase inhibitors T-705 and T-1105 are potential inhibitors of Zika virus replication
title Viral polymerase inhibitors T-705 and T-1105 are potential inhibitors of Zika virus replication
title_full Viral polymerase inhibitors T-705 and T-1105 are potential inhibitors of Zika virus replication
title_fullStr Viral polymerase inhibitors T-705 and T-1105 are potential inhibitors of Zika virus replication
title_full_unstemmed Viral polymerase inhibitors T-705 and T-1105 are potential inhibitors of Zika virus replication
title_short Viral polymerase inhibitors T-705 and T-1105 are potential inhibitors of Zika virus replication
title_sort viral polymerase inhibitors t-705 and t-1105 are potential inhibitors of zika virus replication
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563514/
https://www.ncbi.nlm.nih.gov/pubmed/28597088
http://dx.doi.org/10.1007/s00705-017-3436-8
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