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Tumor cell senescence response produces aggressive variants

Tumors often respond favorably to initial chemotherapy but eventually relapse with drug resistance and increased metastatic potential. Cellular senescence is a major therapeutic outcome of cancer chemotherapy, which leads to tumor stasis or regression through immune clearance of senescent cells. How...

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Detalles Bibliográficos
Autores principales: Yang, Leixiang, Fang, Jia, Chen, Jiandong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563524/
https://www.ncbi.nlm.nih.gov/pubmed/28845296
http://dx.doi.org/10.1038/cddiscovery.2017.49