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Accelerated atherosclerosis development in C57Bl6 mice by overexpressing AAV-mediated PCSK9 and partial carotid ligation

Studying the role of a particular gene in atherosclerosis typically requires a time-consuming and often difficult process of generating double-knockouts or transgenics on ApoE(−/−) or LDL receptor(−/−) background. Recently, it was reported that adeno-associated-virus-8 (AAV8) mediated overexpression...

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Detalles Bibliográficos
Autores principales: Kumar, Sandeep, Kang, Dong-Won, Rezvan, Amir, Jo, Hanjoong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563968/
https://www.ncbi.nlm.nih.gov/pubmed/28504688
http://dx.doi.org/10.1038/labinvest.2017.47