A novel approach to oxoisoaporphine alkaloids via regioselective metalation of alkoxy isoquinolines

Oxoisoaporphine alkaloids are conveniently prepared via direct ring metalation of alkoxy-substituted isoquinolines at C-1, followed by reaction with iodine. Subsequent Suzuki cross-coupling of the resulting 1-iodoisoquinolines to methyl 2-(isoquinolin-1-yl)benzoates and intramolecular acylation of t...

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Detalles Bibliográficos
Autores principales: Melzer, Benedikt C, Bracher, Franz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2017
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564254/
https://www.ncbi.nlm.nih.gov/pubmed/28904605
http://dx.doi.org/10.3762/bjoc.13.156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564254/
https://www.ncbi.nlm.nih.gov/pubmed/28904605
http://dx.doi.org/10.3762/bjoc.13.156

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