Osteoclast proton pump regulator Atp6v1c1 enhances breast cancer growth by activating the mTORC1 pathway and bone metastasis by increasing V-ATPase activity

It is known that V-ATPases (vacuolar H(+)-ATPase) are involved in breast cancer growth and metastasis. Part of this action is similar to their role in osteoclasts, where they’re involved in extracellular acidification and matrix destruction; however, the roles of their subunits in cancer cell prolif...

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Detalles Bibliográficos
Autores principales: McConnell, Matthew, Feng, Shengmei, Chen, Wei, Zhu, Guochun, Shen, Dejun, Ponnazhagan, Selvarangan, Deng, Lianfu, Li, Yi-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564597/
https://www.ncbi.nlm.nih.gov/pubmed/28504970
http://dx.doi.org/10.18632/oncotarget.17544

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564597/
https://www.ncbi.nlm.nih.gov/pubmed/28504970
http://dx.doi.org/10.18632/oncotarget.17544

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