Estrogen-activated MDM2 disrupts mammary tissue architecture through a p53-independent pathway

The Cancer Genome Atlas (TCGA) data indicate that high MDM2 expression correlates with all subtypes of breast cancer. Overexpression of MDM2 drives breast oncogenesis in the presence of wild-type or mutant p53 (mtp53). Importantly, estrogen-receptor positive (ER+) breast cancers overexpress MDM2 and...

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Detalles Bibliográficos
Autores principales: Kundu, Nandini, Brekman, Angelika, Kim, Jun Yeob, Xiao, Gu, Gao, Chong, Bargonetti, Jill
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564615/
https://www.ncbi.nlm.nih.gov/pubmed/28615518
http://dx.doi.org/10.18632/oncotarget.18147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564615/
https://www.ncbi.nlm.nih.gov/pubmed/28615518
http://dx.doi.org/10.18632/oncotarget.18147

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