Pediatric and adult glioblastoma radiosensitization induced by PI3K/mTOR inhibition causes early metabolic alterations detected by nuclear magnetic resonance spectroscopy

Poor outcome for patients with glioblastomas is often associated with radioresistance. PI3K/mTOR pathway deregulation has been correlated with radioresistance; therefore, PI3K/mTOR inhibition could render tumors radiosensitive. In this study, we show that NVP-BEZ235, a dual PI3K/mTOR inhibitor, pote...

Descripción completa

Detalles Bibliográficos
Autores principales: Agliano, Alice, Balarajah, Geetha, Ciobota, Daniela M., Sidhu, Jasmin, Clarke, Paul A., Jones, Chris, Workman, Paul, Leach, Martin O., Al-Saffar, Nada M.S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564619/
https://www.ncbi.nlm.nih.gov/pubmed/28624789
http://dx.doi.org/10.18632/oncotarget.18206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564619/
https://www.ncbi.nlm.nih.gov/pubmed/28624789
http://dx.doi.org/10.18632/oncotarget.18206

Ejemplares similares