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Identifying drug-pathway association pairs based on L1L2,1-integrative penalized matrix decomposition
The traditional methods of drug discovery follow the “one drug-one target” approach, which ignores the cellular and physiological environment of the action mechanism of drugs. However, pathway-based drug discovery methods can overcome this limitation. This kind of method, such as the Integrative Pen...
Autores principales: | Wang, Dong-Qin, Gao, Ying-Lian, Liu, Jin-Xing, Zheng, Chun-Hou, Kong, Xiang-Zhen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564627/ https://www.ncbi.nlm.nih.gov/pubmed/28624800 http://dx.doi.org/10.18632/oncotarget.18254 |
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