c-Fos-dependent miR-22 targets MDC1 and regulates DNA repair in terminally differentiated cells

Terminally differentiated cells have a reduced capacity to repair double-stranded breaks (DSB) in DNA, however, the underlying molecular mechanism remains unclear. Here, we show that miR-22 is upregulated during postmitotic differentiation of human breast MCF-7 cells, hematopoietic HL60 and K562 cel...

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Detalles Bibliográficos
Autores principales: Lee, Jung-Hee, Park, Seon-Joo, Kim, Seok Won, Hariharasudhan, Gurusamy, Jung, Sung-Mi, Jun, Semo, Yong, Jeongsik, You, Ho Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564639/
https://www.ncbi.nlm.nih.gov/pubmed/28637007
http://dx.doi.org/10.18632/oncotarget.18389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564639/
https://www.ncbi.nlm.nih.gov/pubmed/28637007
http://dx.doi.org/10.18632/oncotarget.18389

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