Targeting protein homeostasis with nelfinavir/salinomycin dual therapy effectively induces death of mTORC1 hyperactive cells

Uncontrolled cell growth in Tuberous Sclerosis Complex occurs due to inappropriate activation of mechanistic (mammalian) target of rapamycin complex 1 (mTORC1). The current therapy, rapamycin, produced promising clinical trial results, but patient tumours regrow if treatment is discontinued, reveali...

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Detalles Bibliográficos
Autores principales: Dunlop, Elaine A., Johnson, Charlotte E., Wiltshire, Marie, Errington, Rachel J., Tee, Andrew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564719/
https://www.ncbi.nlm.nih.gov/pubmed/28415776
http://dx.doi.org/10.18632/oncotarget.16232

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564719/
https://www.ncbi.nlm.nih.gov/pubmed/28415776
http://dx.doi.org/10.18632/oncotarget.16232

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