Myc-induced glutaminolysis bypasses HIF-driven glycolysis in hypoxic small cell lung carcinoma cells

We previously demonstrated that small cell lung carcinoma (SCLC) cells lack HIF-2α protein expression, whereas HIF-1α in these cells is expressed at both acute and prolonged hypoxia. Here we show that low HIF2A expression correlates with high expression of MYC genes. Knockdown of HIF1A expression ha...

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Detalles Bibliográficos
Autores principales: Thorén, Matilda Munksgaard, Vaapil, Marica, Staaf, Johan, Planck, Maria, Johansson, Martin E., Mohlin, Sofie, Påhlman, Sven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564742/
https://www.ncbi.nlm.nih.gov/pubmed/28430666
http://dx.doi.org/10.18632/oncotarget.16904

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564742/
https://www.ncbi.nlm.nih.gov/pubmed/28430666
http://dx.doi.org/10.18632/oncotarget.16904

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