In silico gene expression analysis reveals glycolysis and acetate anaplerosis in IDH1 wild-type glioma and lactate and glutamate anaplerosis in IDH1-mutated glioma

Hotspot mutations in isocitrate dehydrogenase 1 (IDH1) initiate low-grade glioma and secondary glioblastoma and induce a neomorphic activity that converts α-ketoglutarate (α-KG) to the oncometabolite D-2-hydroxyglutarate (D-2-HG). It causes metabolic rewiring that is not fully understood. We investi...

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Detalles Bibliográficos
Autores principales: Khurshed, Mohammed, Molenaar, Remco J., Lenting, Krissie, Leenders, William P., van Noorden, Cornelis J.F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564758/
https://www.ncbi.nlm.nih.gov/pubmed/28467784
http://dx.doi.org/10.18632/oncotarget.17106

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564758/
https://www.ncbi.nlm.nih.gov/pubmed/28467784
http://dx.doi.org/10.18632/oncotarget.17106

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