Dual degradation signals destruct GLI1: AMPK inhibits GLI1 through β-TrCP-mediated proteasome degradation

Overexpression of the GLI1 gene has frequently been found in various cancer types, particularly in brain tumors, in which aberrant GLI1 induction promotes cancer cell growth. Therefore, identifying the molecular players controlling GLI1 expression is of clinical importance. Previously, we reported t...

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Detalles Bibliográficos
Autores principales: Zhang, Rui, Huang, Sherri Y., Ka-Wai Li, Kay, Li, Yen-Hsing, Hsu, Wei-Hsuan, Zhang, Guang Jun, Chang, Chun-Ju, Yang, Jer-Yen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564814/
https://www.ncbi.nlm.nih.gov/pubmed/28562331
http://dx.doi.org/10.18632/oncotarget.17769

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564814/
https://www.ncbi.nlm.nih.gov/pubmed/28562331
http://dx.doi.org/10.18632/oncotarget.17769

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