Cargando…

Dual degradation signals destruct GLI1: AMPK inhibits GLI1 through β-TrCP-mediated proteasome degradation

Overexpression of the GLI1 gene has frequently been found in various cancer types, particularly in brain tumors, in which aberrant GLI1 induction promotes cancer cell growth. Therefore, identifying the molecular players controlling GLI1 expression is of clinical importance. Previously, we reported t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Rui, Huang, Sherri Y., Ka-Wai Li, Kay, Li, Yen-Hsing, Hsu, Wei-Hsuan, Zhang, Guang Jun, Chang, Chun-Ju, Yang, Jer-Yen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564814/ https://www.ncbi.nlm.nih.gov/pubmed/28562331 http://dx.doi.org/10.18632/oncotarget.17769

Ejemplares similares

Structural basis of βTrCP1-associated GLI3 processing
por: Shafique, Shagufta, et al.
Publicado: (2019)

Plk1- and β-TrCP–dependent degradation of Bora controls mitotic progression
por: Seki, Akiko, et al.
Publicado: (2008)

SCF(βTrCP)-mediated degradation of SHARP1 in triple-negative breast cancer
por: Enriqué Steinberg, Juliana Haydeé, et al.
Publicado: (2023)

PLK1 and β-TrCP-Dependent Ubiquitination and Degradation of Rap1GAP Controls Cell Proliferation
por: Wang, Dejie, et al.
Publicado: (2014)

β-TrCP-mediated ubiquitination and degradation of liver-enriched transcription factor CREB-H
por: Cheng, Yun, et al.
Publicado: (2016)

βTrCP controls the lysosome-mediated degradation of CDK1, whose accumulation correlates with tumor malignancy
por: Herrero-Ruiz, Joaquín, et al.
Publicado: (2014)

ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP
por: Bufalieri, Francesca, et al.
Publicado: (2019)

Small molecule and peptide inhibitors of βTrCP and the βTrCP–NRF2 protein–protein interaction
por: Jaffry, Uzma, et al.
Publicado: (2023)

SCFβ‐TrCP ubiquitinates CHK1 in an AMPK‐dependent manner in response to glucose deprivation
por: Ma, Ying, et al.
Publicado: (2018)

Rotavirus NSP1 Inhibits NFκB Activation by Inducing Proteasome-Dependent Degradation of β-TrCP: A Novel Mechanism of IFN Antagonism
por: Graff, Joel W., et al.
Publicado: (2009)

AMPK-Mediated Phosphorylation of Nrf2 at S374/S408/S433 Favors Its βTrCP2-Mediated Degradation in KEAP1-Deficient Cells
por: Petsouki, Eleni, et al.
Publicado: (2023)

β-TrCP-mediated ubiquitination and degradation of Dlg5 regulates hepatocellular carcinoma cell proliferation
por: Wang, Dongping, et al.
Publicado: (2019)

Plk1 regulates mitotic Aurora A function through βTrCP-dependent degradation of hBora
por: Chan, Eunice H. Y., et al.
Publicado: (2008)

β-TrCP- and Casein Kinase II-Mediated Degradation of Cyclin F Controls Timely Mitotic Progression
por: Mavrommati, Ioanna, et al.
Publicado: (2018)

ER-stress promotes VHL-independent degradation of hypoxia-inducible factors via FBXW1A/βTrCP
por: Mennerich, Daniela, et al.
Publicado: (2022)

Mebendazole Mediates Proteasomal Degradation of GLI Transcription Factors in Acute Myeloid Leukemia
por: Freisleben, Fabian, et al.
Publicado: (2021)

Combination of artesunate and WNT974 induces KRAS protein degradation by upregulating E3 ligase ANACP2 and β-TrCP in the ubiquitin–proteasome pathway
por: Gong, Rui-Hong, et al.
Publicado: (2022)

β-TrCP1 facilitates cell cycle checkpoint activation, DNA repair, and cell survival through ablation of β-TrCP2 in response to genotoxic stress
por: Islam, Sehbanul, et al.
Publicado: (2021)

Regulated Degradation of the HIV-1 Vpu Protein through a βTrCP-Independent Pathway Limits the Release of Viral Particles
por: Estrabaud, Emilie, et al.
Publicado: (2007)

PGE2-JNK signaling axis non-canonically promotes Gli activation by protecting Gli2 from ubiquitin-proteasomal degradation
por: Yang, Jun, et al.
Publicado: (2021)

NORE1A Regulates MDM2 Via β-TrCP
por: Schmidt, M. Lee, et al.
Publicado: (2016)

Inhibition of FOXO3 Tumor Suppressor Function by βTrCP1 through Ubiquitin-Mediated Degradation in a Tumor Mouse Model
por: Tsai, Wen-Bin, et al.
Publicado: (2010)

HIV-1 Vpu Neutralizes the Antiviral Factor Tetherin/BST-2 by Binding It and Directing Its Beta-TrCP2-Dependent Degradation
por: Mangeat, Bastien, et al.
Publicado: (2009)

GSK-3β phosphorylation-dependent degradation of ZNF281 by β-TrCP2 suppresses colorectal cancer progression
por: Zhu, Yuekun, et al.
Publicado: (2017)

GSK3-β Stimulates Claspin Degradation via β-TrCP Ubiquitin Ligase and Alters Cancer Cell Survival
por: Cabrera, Elisa, et al.
Publicado: (2019)

Comparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex
por: Ding, Siyuan, et al.
Publicado: (2016)

β-TrCP1 degradation is a novel action mechanism of PI3K/mTOR inhibitors in triple-negative breast cancer cells
por: Yi, Yong Weon, et al.
Publicado: (2015)

E3 Ligase SCF(βTrCP)-induced DYRK1A Protein Degradation Is Essential for Cell Cycle Progression in HEK293 Cells
por: Liu, Qiang, et al.
Publicado: (2016)

Degradation of helicase-like transcription factor (HLTF) by β-TrCP promotes hepatocarcinogenesis via activation of the p62/mTOR axis
por: Tan, Ye, et al.
Publicado: (2023)

USP7 counteracts SCF(βTrCP)- but not APC(Cdh1)-mediated proteolysis of Claspin
por: Faustrup, Helene, et al.
Publicado: (2009)

SCF(β-TrCP)-mediated degradation of TOP2β promotes cancer cell survival in response to chemotherapeutic drugs targeting topoisomerase II
por: Shu, Jianfeng, et al.
Publicado: (2020)

F-box Protein βTrCP1 Is a Substrate of Extracellular Signal-regulated Kinase 2
por: Lee, Cheol-Jung, et al.
Publicado: (2021)

The E3 ubiquitin ligases β-TrCP and FBXW7 cooperatively mediates GSK3-dependent Mcl-1 degradation induced by the Akt inhibitor API-1, resulting in apoptosis
por: Ren, Hui, et al.
Publicado: (2013)

Datasets from an interaction proteomics screen for substrates of the SCF(βTrCP) ubiquitin ligase
por: Magliozzi, Roberto, et al.
Publicado: (2015)

Involvement of p38-βTrCP-Tristetraprolin-TNFα axis in radiation pneumonitis
por: Krishnamurthy, Pranathi Meda, et al.
Publicado: (2017)

The cross talk of two family members of β-TrCP in the regulation of cell autophagy and growth
por: Cui, Danrui, et al.
Publicado: (2019)

Revealing β-TrCP activity dynamics in live cells with a genetically encoded biosensor
por: Paul, Debasish, et al.
Publicado: (2022)

The tripeptide N-Cbz-βGly-Gly-Gly-Obz
por: Nicholas, Sumesh
Publicado: (2015)

SAG/RBX2 E3 ligase complexes with UBCH10 and UBE2S E2s to ubiquitylate β-TrCP1 via K11-linkage for degradation
por: Kuang, Peng, et al.
Publicado: (2016)

β-TrCP is dispensable for Vpu's ability to overcome the CD317/Tetherin-imposed restriction to HIV-1 release
por: Tervo, Hanna-Mari, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_3s4nirihb4ep79k6scrnvc9o5q