Structural recognition of tubulysin B derivatives by multidrug resistance efflux transporters in human cancer cells

Multidrug resistance (MDR) is a major hindrance to curative chemotherapy of various human malignancies. Hence, novel chemotherapeutics must be evaluated for their recognition by MDR efflux transporters. Herein we explored the cytotoxic activity of synthetic tubulysin B (Tub-B, EC1009) derivatives (T...

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Detalles Bibliográficos
Autores principales: Stark, Michal, Assaraf, Yehuda G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564821/
https://www.ncbi.nlm.nih.gov/pubmed/28637003
http://dx.doi.org/10.18632/oncotarget.18385

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564821/
https://www.ncbi.nlm.nih.gov/pubmed/28637003
http://dx.doi.org/10.18632/oncotarget.18385

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