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Structural recognition of tubulysin B derivatives by multidrug resistance efflux transporters in human cancer cells
Multidrug resistance (MDR) is a major hindrance to curative chemotherapy of various human malignancies. Hence, novel chemotherapeutics must be evaluated for their recognition by MDR efflux transporters. Herein we explored the cytotoxic activity of synthetic tubulysin B (Tub-B, EC1009) derivatives (T...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Impact Journals LLC
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564821/ https://www.ncbi.nlm.nih.gov/pubmed/28637003 http://dx.doi.org/10.18632/oncotarget.18385 |