The role of desmosomes in carcinogenesis

Desmosomes, which are intercellular adhesive complexes, are essential for the maintenance of epithelial homeostasis. They are located at the cell membrane, where they act as anchors for intermediate filaments. Downregulation of desmosome proteins in various cancers promotes tumor progression. Howeve...

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Detalles Bibliográficos
Autores principales: Zhou, Guangxin, Yang, Linlin, Gray, Ashley, Srivastava, Amit Kumar, Li, Cuiping, Zhang, Gongwen, Cui, Tiantian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565390/
https://www.ncbi.nlm.nih.gov/pubmed/28860814
http://dx.doi.org/10.2147/OTT.S136367
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author Zhou, Guangxin
Yang, Linlin
Gray, Ashley
Srivastava, Amit Kumar
Li, Cuiping
Zhang, Gongwen
Cui, Tiantian
author_facet Zhou, Guangxin
Yang, Linlin
Gray, Ashley
Srivastava, Amit Kumar
Li, Cuiping
Zhang, Gongwen
Cui, Tiantian
author_sort Zhou, Guangxin
collection PubMed
description Desmosomes, which are intercellular adhesive complexes, are essential for the maintenance of epithelial homeostasis. They are located at the cell membrane, where they act as anchors for intermediate filaments. Downregulation of desmosome proteins in various cancers promotes tumor progression. However, the role of desmosomes in carcinogenesis is still being elucidated. Recent studies revealed that desmosome family members play a crucial role in tumor suppression or tumor promotion. This review focuses on studies that provide insights into the role of desmosomes in carcinogenesis and address their molecular functions.
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spelling pubmed-55653902017-08-31 The role of desmosomes in carcinogenesis Zhou, Guangxin Yang, Linlin Gray, Ashley Srivastava, Amit Kumar Li, Cuiping Zhang, Gongwen Cui, Tiantian Onco Targets Ther Review Desmosomes, which are intercellular adhesive complexes, are essential for the maintenance of epithelial homeostasis. They are located at the cell membrane, where they act as anchors for intermediate filaments. Downregulation of desmosome proteins in various cancers promotes tumor progression. However, the role of desmosomes in carcinogenesis is still being elucidated. Recent studies revealed that desmosome family members play a crucial role in tumor suppression or tumor promotion. This review focuses on studies that provide insights into the role of desmosomes in carcinogenesis and address their molecular functions. Dove Medical Press 2017-08-14 /pmc/articles/PMC5565390/ /pubmed/28860814 http://dx.doi.org/10.2147/OTT.S136367 Text en © 2017 Zhou et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Zhou, Guangxin
Yang, Linlin
Gray, Ashley
Srivastava, Amit Kumar
Li, Cuiping
Zhang, Gongwen
Cui, Tiantian
The role of desmosomes in carcinogenesis
title The role of desmosomes in carcinogenesis
title_full The role of desmosomes in carcinogenesis
title_fullStr The role of desmosomes in carcinogenesis
title_full_unstemmed The role of desmosomes in carcinogenesis
title_short The role of desmosomes in carcinogenesis
title_sort role of desmosomes in carcinogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565390/
https://www.ncbi.nlm.nih.gov/pubmed/28860814
http://dx.doi.org/10.2147/OTT.S136367
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