AB026. Experience on diagnosis and treatment of non-obstructive azoospermia

BACKGROUND: To analyze the status of diagnosis and treatment of non-obstructive azoospermia, and to introduce the experience on diagnosis and treatment of non-obstructive azoospermia. METHODS: Read the literature. The clinical characteristics such as sex hormones, testicular volume, chromosome karyotype and microdeletion of AZF gene of non-obstructive azoospermia patients were analyzed in this paper, and the gains and losses were analyzed in the course of diagnosis and treatment. RESULTS: Drug preparation before sperm retrieval can help improve the success rate. Different causes of non-obstructive azoospermia have different success rate. Treatment of non-obstructive azoospermia should respect the individual wishes. CONCLUSIONS: Non-obstructive azoospermia is a difficult problem in the field of male infertility. The reason is that we know little about its cause. Even if some patients can get etiological diagnosis, there is no exact etiological treatment. A small amount of sperm can be found in the semen for a small number of patients through the empirical drug treatment, they have access to offspring through scarce sperm cryopreservation techniques. Most patients eventually need surgery to obtain sperm. There are many ways of surgery, in which highest probability of obtaining sperm is microdissection testicular sperm extraction. Success rate for sperm retrieval is 20–60%. Unfortunately, there is still no reliable means to predict whether a sperm retrieval will be successful. With the development of molecular biology, I believe that in the near future more non-obstructive azoospermia patients can be effectively treated.