Diabetes Exacerbates Infection via Hyperinflammation by Signaling through TLR4 and RAGE

For more than a century, diabetic patients have been considered immunosuppressed due to defects in phagocytosis and microbial killing. We confirmed that diabetic mice were hypersusceptible to bacteremia caused by Gram-negative bacteria (GNB), dying at inocula nonlethal to nondiabetic mice. Contrary...

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Detalles Bibliográficos
Autores principales: Nielsen, Travis B., Pantapalangkoor, Paul, Yan, Jun, Luna, Brian M., Dekitani, Ken, Bruhn, Kevin, Tan, Brandon, Junus, Justin, Bonomo, Robert A., Schmidt, Ann Marie, Everson, Michael, Duncanson, Frederick, Doherty, Terence M., Lin, Lin, Spellberg, Brad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565964/
https://www.ncbi.nlm.nih.gov/pubmed/28830942
http://dx.doi.org/10.1128/mBio.00818-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565964/
https://www.ncbi.nlm.nih.gov/pubmed/28830942
http://dx.doi.org/10.1128/mBio.00818-17

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