Epigenetically induced ectopic expression of UNCX impairs the proliferation and differentiation of myeloid cells

We here describe a leukemogenic role of the homeobox gene UNCX, activated by epigenetic modifications in acute myeloid leukemia (AML). We found the ectopic activation of UNCX in a leukemia patient harboring a t(7;10)(p22;p14) translocation, in 22 of 61 of additional cases [a total of 23 positive pat...

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Detalles Bibliográficos
Autores principales: Daniele, Giulia, Simonetti, Giorgia, Fusilli, Caterina, Iacobucci, Ilaria, Lonoce, Angelo, Palazzo, Antonio, Lomiento, Mariana, Mammoli, Fabiana, Marsano, Renè Massimiliano, Marasco, Elena, Mantovani, Vilma, Quentmeier, Hilmar, Drexler, Hans G, Ding, Jie, Palumbo, Orazio, Carella, Massimo, Nadarajah, Niroshan, Perricone, Margherita, Ottaviani, Emanuela, Baldazzi, Carmen, Testoni, Nicoletta, Papayannidis, Cristina, Ferrari, Sergio, Mazza, Tommaso, Martinelli, Giovanni, Storlazzi, Clelia Tiziana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566027/
https://www.ncbi.nlm.nih.gov/pubmed/28411256
http://dx.doi.org/10.3324/haematol.2016.163022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566027/
https://www.ncbi.nlm.nih.gov/pubmed/28411256
http://dx.doi.org/10.3324/haematol.2016.163022

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