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A three-dimensional ex vivo tri-culture model mimics cell-cell interactions between acute myeloid leukemia and the vascular niche

Ex vivo studies of human disease, such as acute myeloid leukemia, are generally limited to the analysis of two-dimensional cultures which often misinterpret the effectiveness of chemotherapeutics and other treatments. Here we show that matrix metalloproteinase-sensitive hydrogels prepared from poly(...

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Detalles Bibliográficos
Autores principales: Bray, Laura J., Binner, Marcus, Körner, Yvonne, von Bonin, Malte, Bornhäuser, Martin, Werner, Carsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566030/
https://www.ncbi.nlm.nih.gov/pubmed/28360147
http://dx.doi.org/10.3324/haematol.2016.157883