Cargando…

Transcriptional dysregulation of Interferome in experimental and human Multiple Sclerosis

Recent evidence indicates that single multiple sclerosis (MS) susceptibility genes involved in interferon (IFN) signaling display altered transcript levels in peripheral blood of untreated MS subjects, suggesting that responsiveness to endogenous IFN is dysregulated during neuroinflammation. To prov...

Descripción completa

Detalles Bibliográficos
Autores principales:	Srinivasan, Sundararajan, Severa, Martina, Rizzo, Fabiana, Menon, Ramesh, Brini, Elena, Mechelli, Rosella, Martinelli, Vittorio, Hertzog, Paul, Salvetti, Marco, Furlan, Roberto, Martino, Gianvito, Comi, Giancarlo, Coccia, Eliana M., Farina, Cinthia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566335/ https://www.ncbi.nlm.nih.gov/pubmed/28827704 http://dx.doi.org/10.1038/s41598-017-09286-y

Ejemplares similares

Author Correction: Transcriptional dysregulation of Interferome in experimental and human Multiple Sclerosis
por: Srinivasan, Sundararajan, et al.
Publicado: (2018)

Dysregulation of MS risk genes and pathways at distinct stages of disease
por: Srinivasan, Sundararajan, et al.
Publicado: (2017)

Three Decades of Interferon-β in Multiple Sclerosis: Can We Repurpose This Information for the Management of SARS-CoV2 Infection?
por: Severa, Martina, et al.
Publicado: (2020)

INTERFEROME: the database of interferon regulated genes
por: Samarajiwa, Shamith A., et al.
Publicado: (2009)

INTERFEROME v2.0: an updated database of annotated interferon-regulated genes
por: Rusinova, Irina, et al.
Publicado: (2013)

Innate Immune Response to SARS-CoV-2 Infection: From Cells to Soluble Mediators
por: Ricci, Daniela, et al.
Publicado: (2021)

Increased CD8+ T Cell Response to Epstein-Barr Virus Lytic Antigens in the Active Phase of Multiple Sclerosis
por: Angelini, Daniela F., et al.
Publicado: (2013)

The antiviral state has shaped the CpG composition of the vertebrate interferome to avoid self-targeting
por: Shaw, Andrew E., et al.
Publicado: (2021)

Interferome signature dynamics during the anti-dengue immune response: a systems biology characterization
por: Usuda, Júlia Nakanishi, et al.
Publicado: (2023)

Siponimod (BAF312) Activates Nrf2 While Hampering NFκB in Human Astrocytes, and Protects From Astrocyte-Induced Neurodegeneration
por: Colombo, Emanuela, et al.
Publicado: (2020)

Myeloid cells as target of fingolimod action in multiple sclerosis
por: Di Dario, Marco, et al.
Publicado: (2015)

Inferring Multiple Sclerosis Stages from the Blood Transcriptome via Machine Learning
por: Acquaviva, Massimo, et al.
Publicado: (2020)

Thymosins in multiple sclerosis and its experimental models: moving from basic to clinical application
por: Severa, Martina, et al.
Publicado: (2019)

Impact of Mycobacterium tuberculosis RD1-locus on human primary dendritic cell immune functions
por: Etna, Marilena P., et al.
Publicado: (2015)

Differential Responses of Human Dendritic Cells to Live or Inactivated Staphylococcus aureus: Impact on Cytokine Production and T Helper Expansion
por: Cruciani, Melania, et al.
Publicado: (2019)

Laquinimod Modulates Human Astrocyte Function and Dampens Astrocyte-Induced Neurotoxicity during Inflammation
por: Colombo, Emanuela, et al.
Publicado: (2020)

Human plasmacytoid dendritic cells at the crossroad of type I interferon-regulated B cell differentiation and antiviral response to tick-borne encephalitis virus
por: Etna, Marilena P., et al.
Publicado: (2021)

Loss of Circulating CD8+ CD161(high) T Cells in Primary Progressive Multiple Sclerosis
por: Acquaviva, Massimo, et al.
Publicado: (2019)

The phenotypic convergence between microglia and peripheral macrophages during development and neuroinflammation paves the way for new therapeutic perspectives
por: Grassivaro, Francesca, et al.
Publicado: (2020)

Novel evidence of Thymosin α1 immunomodulatory properties in SARS-CoV-2 infection: Effect on innate inflammatory response in a peripheral blood mononuclear cell-based in vitro model
por: Ricci, Daniela, et al.
Publicado: (2023)

In Vivo Fate Analysis Reveals the Multipotent and Self-Renewal Features of Embryonic AspM Expressing Cells
por: Marinaro, Cinzia, et al.
Publicado: (2011)

T Regulatory Cells Are Markers of Disease Activity in Multiple Sclerosis Patients
por: Dalla Libera, Dacia, et al.
Publicado: (2011)

Free Light Chains and Intrathecal B Cells Activity in Multiple Sclerosis: A Prospective Study and Meta-Analysis
por: Passerini, Gabriella, et al.
Publicado: (2016)

Prognostic value of serum neurofilaments in patients with clinically isolated syndromes
por: Dalla Costa, Gloria, et al.
Publicado: (2019)

A specific anti‐COVID‐19 BNT162b2 vaccine‐induced early innate immune signature positively correlates with the humoral protective response in healthy and multiple sclerosis vaccine recipients
por: Severa, Martina, et al.
Publicado: (2023)

iAstrocytes do not restrain T cell proliferation in vitro
por: Colombo, Emanuela, et al.
Publicado: (2023)

Chicken interferome: avian interferon-stimulated genes identified by microarray and RNA-seq of primary chick embryo fibroblasts treated with a chicken type I interferon (IFN-α)
por: Giotis, Efstathios S., et al.
Publicado: (2016)

Genome-Wide Gene Expression Analysis of Mtb-Infected DC Highlights the Rapamycin-Driven Modulation of Regulatory Cytokines via the mTOR/GSK-3β Axis
por: Etna, Marilena P., et al.
Publicado: (2021)

Shared Molecular and Functional Frameworks among Five Complex Human Disorders: A Comparative Study on Interactomes Linked to Susceptibility Genes
por: Menon, Ramesh, et al.
Publicado: (2011)

Staphylococcus aureus Esx Factors Control Human Dendritic Cell Functions Conditioning Th1/Th17 Response
por: Cruciani, Melania, et al.
Publicado: (2017)

ISG15 protects human Tregs from interferon alpha‐induced contraction in a cell‐intrinsic fashion
por: Pacella, Ilenia, et al.
Publicado: (2020)

Mycobacterium tuberculosis-induced miR-155 subverts autophagy by targeting ATG3 in human dendritic cells
por: Etna, Marilena P., et al.
Publicado: (2018)

Interleukin 4 modulates microglia homeostasis and attenuates the early slowly progressive phase of amyotrophic lateral sclerosis
por: Rossi, Chiara, et al.
Publicado: (2018)

A Mechanistic, Stochastic Model Helps Understand Multiple Sclerosis Course and Pathogenesis
por: Bordi, Isabella, et al.
Publicado: (2013)

Genome-Wide Multiple Sclerosis Association Data and Coagulation
por: La Starza, Sara, et al.
Publicado: (2019)

EBNA2 Binds to Genomic Intervals Associated with Multiple Sclerosis and Overlaps with Vitamin D Receptor Occupancy
por: Ricigliano, Vito A. G., et al.
Publicado: (2015)

Increased Circulating Levels of Vitamin D Binding Protein in MS Patients
por: Rinaldi, Arturo Ottavio, et al.
Publicado: (2015)

Differential plasmacytoid dendritic cell phenotype and type I Interferon response in asymptomatic and severe COVID-19 infection
por: Severa, Martina, et al.
Publicado: (2021)

Cytokines Stimulate the Release of Microvesicles from Myeloid Cells Independently from the P2X7 Receptor/Acid Sphingomyelinase Pathway
por: Colombo, Federico, et al.
Publicado: (2018)

Reworking GWAS Data to Understand the Role of Nongenetic Factors in MS Etiopathogenesis
por: Mechelli, Rosella, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_s0lnnuq3q3qcn0qpt0k480undc