Juxtacrine Activity of Estrogen Receptor α in Uterine Stromal Cells is Necessary for Estrogen-Induced Epithelial Cell Proliferation

Aberrant regulation of uterine cell growth can lead to endometrial cancer and infertility. To understand the molecular mechanisms of estrogen-induced uterine cell growth, we removed the estrogen receptor α (Esr1) from mouse uterine stromal cells, where the embryo is implanted during pregnancy. Witho...

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Autores principales: Winuthayanon, Wipawee, Lierz, Sydney L., Delarosa, Karena C., Sampels, Skylar R., Donoghue, Lauren J., Hewitt, Sylvia C., Korach, Kenneth S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566397/
https://www.ncbi.nlm.nih.gov/pubmed/28827707
http://dx.doi.org/10.1038/s41598-017-07728-1
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author Winuthayanon, Wipawee
Lierz, Sydney L.
Delarosa, Karena C.
Sampels, Skylar R.
Donoghue, Lauren J.
Hewitt, Sylvia C.
Korach, Kenneth S.
author_facet Winuthayanon, Wipawee
Lierz, Sydney L.
Delarosa, Karena C.
Sampels, Skylar R.
Donoghue, Lauren J.
Hewitt, Sylvia C.
Korach, Kenneth S.
author_sort Winuthayanon, Wipawee
collection PubMed
description Aberrant regulation of uterine cell growth can lead to endometrial cancer and infertility. To understand the molecular mechanisms of estrogen-induced uterine cell growth, we removed the estrogen receptor α (Esr1) from mouse uterine stromal cells, where the embryo is implanted during pregnancy. Without ESR1 in neighboring stroma cells, epithelial cells that line the inside of the uterus are unable to grow due to a lack of growth factors secreted from adjacent stromal cells. Moreover, loss of stromal ESR1 caused mice to deliver fewer pups due in part due to inability of some embryos to implant in the uterus, indicating that stromal ESR1 is crucial for uterine cell growth and pregnancy.
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spelling pubmed-55663972017-08-23 Juxtacrine Activity of Estrogen Receptor α in Uterine Stromal Cells is Necessary for Estrogen-Induced Epithelial Cell Proliferation Winuthayanon, Wipawee Lierz, Sydney L. Delarosa, Karena C. Sampels, Skylar R. Donoghue, Lauren J. Hewitt, Sylvia C. Korach, Kenneth S. Sci Rep Article Aberrant regulation of uterine cell growth can lead to endometrial cancer and infertility. To understand the molecular mechanisms of estrogen-induced uterine cell growth, we removed the estrogen receptor α (Esr1) from mouse uterine stromal cells, where the embryo is implanted during pregnancy. Without ESR1 in neighboring stroma cells, epithelial cells that line the inside of the uterus are unable to grow due to a lack of growth factors secreted from adjacent stromal cells. Moreover, loss of stromal ESR1 caused mice to deliver fewer pups due in part due to inability of some embryos to implant in the uterus, indicating that stromal ESR1 is crucial for uterine cell growth and pregnancy. Nature Publishing Group UK 2017-08-21 /pmc/articles/PMC5566397/ /pubmed/28827707 http://dx.doi.org/10.1038/s41598-017-07728-1 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Winuthayanon, Wipawee
Lierz, Sydney L.
Delarosa, Karena C.
Sampels, Skylar R.
Donoghue, Lauren J.
Hewitt, Sylvia C.
Korach, Kenneth S.
Juxtacrine Activity of Estrogen Receptor α in Uterine Stromal Cells is Necessary for Estrogen-Induced Epithelial Cell Proliferation
title Juxtacrine Activity of Estrogen Receptor α in Uterine Stromal Cells is Necessary for Estrogen-Induced Epithelial Cell Proliferation
title_full Juxtacrine Activity of Estrogen Receptor α in Uterine Stromal Cells is Necessary for Estrogen-Induced Epithelial Cell Proliferation
title_fullStr Juxtacrine Activity of Estrogen Receptor α in Uterine Stromal Cells is Necessary for Estrogen-Induced Epithelial Cell Proliferation
title_full_unstemmed Juxtacrine Activity of Estrogen Receptor α in Uterine Stromal Cells is Necessary for Estrogen-Induced Epithelial Cell Proliferation
title_short Juxtacrine Activity of Estrogen Receptor α in Uterine Stromal Cells is Necessary for Estrogen-Induced Epithelial Cell Proliferation
title_sort juxtacrine activity of estrogen receptor α in uterine stromal cells is necessary for estrogen-induced epithelial cell proliferation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566397/
https://www.ncbi.nlm.nih.gov/pubmed/28827707
http://dx.doi.org/10.1038/s41598-017-07728-1
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