Small molecules enhance CRISPR/Cas9-mediated homology-directed genome editing in primary cells

CRISPR/Cas9 is an efficient customizable nuclease to generate double-strand breaks (DSBs) in the genome. This process results in knockout of the targeted gene or knock-in of a specific DNA fragment at the targeted locus in the genome of various species. However, efficiency of knock-in mediated by ho...

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Detalles Bibliográficos
Autores principales: Li, Guoling, Zhang, Xianwei, Zhong, Cuili, Mo, Jianxin, Quan, Rong, Yang, Jie, Liu, Dewu, Li, Zicong, Yang, Huaqiang, Wu, Zhenfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566437/
https://www.ncbi.nlm.nih.gov/pubmed/28827551
http://dx.doi.org/10.1038/s41598-017-09306-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566437/
https://www.ncbi.nlm.nih.gov/pubmed/28827551
http://dx.doi.org/10.1038/s41598-017-09306-x

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