Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type

Amyloid aggregates found in the brain of patients with neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are thought to spread to increasingly larger areas of the brain through a prion-like seeding mechanism. Not much is known about which cell surface receptors may be involv...

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Detalles Bibliográficos
Autores principales: Ihse, Elisabet, Yamakado, Hodaka, van Wijk, Xander M., Lawrence, Roger, Esko, Jeffrey D., Masliah, Eliezer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566500/
https://www.ncbi.nlm.nih.gov/pubmed/28827536
http://dx.doi.org/10.1038/s41598-017-08720-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566500/
https://www.ncbi.nlm.nih.gov/pubmed/28827536
http://dx.doi.org/10.1038/s41598-017-08720-5

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