Nei-like 1 (NEIL1) excises 5-carboxylcytosine directly and stimulates TDG-mediated 5-formyl and 5-carboxylcytosine excision

Thymine DNA glycosylase (TDG) and Nei-like 1 (NEIL1) have both been implicated in the base excision repair step of active DNA demethylation. The robust glycosylase activity of TDG on DNA substrates containing 5-formylcytosine (5fC) or 5-carboxylcytosine (5caC) is universally accepted, but the mode o...

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Detalles Bibliográficos
Autores principales: Slyvka, Anton, Mierzejewska, Karolina, Bochtler, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566547/
https://www.ncbi.nlm.nih.gov/pubmed/28827588
http://dx.doi.org/10.1038/s41598-017-07458-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566547/
https://www.ncbi.nlm.nih.gov/pubmed/28827588
http://dx.doi.org/10.1038/s41598-017-07458-4

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