Cargando…

Nei-like 1 (NEIL1) excises 5-carboxylcytosine directly and stimulates TDG-mediated 5-formyl and 5-carboxylcytosine excision

Thymine DNA glycosylase (TDG) and Nei-like 1 (NEIL1) have both been implicated in the base excision repair step of active DNA demethylation. The robust glycosylase activity of TDG on DNA substrates containing 5-formylcytosine (5fC) or 5-carboxylcytosine (5caC) is universally accepted, but the mode o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Slyvka, Anton, Mierzejewska, Karolina, Bochtler, Matthias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566547/ https://www.ncbi.nlm.nih.gov/pubmed/28827588 http://dx.doi.org/10.1038/s41598-017-07458-4

Ejemplares similares

Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation
por: Hashimoto, Hideharu, et al.
Publicado: (2012)

5-Carboxylcytosine levels are elevated in human breast cancers and gliomas
por: Eleftheriou, Maria, et al.
Publicado: (2015)

MAX is an epigenetic sensor of 5-carboxylcytosine and is altered in multiple myeloma
por: Wang, Dongxue, et al.
Publicado: (2017)

Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA
por: Zhang, Liang, et al.
Publicado: (2012)

5-Carboxylcytosine is localized to euchromatic regions in the nuclei of follicular cells in axolotl ovary
por: Alioui, Anthony, et al.
Publicado: (2012)

Guanine- 5-carboxylcytosine base pairs mimic mismatches during DNA replication
por: Shibutani, Toshihiro, et al.
Publicado: (2014)

Medulloblastoma and ependymoma cells display increased levels of 5-carboxylcytosine and elevated TET1 expression
por: Ramsawhook, Ashley, et al.
Publicado: (2017)

LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames
por: Blythe, Martin J., et al.
Publicado: (2021)

Tissue-Specific Differences in DNA Modifications (5-Hydroxymethylcytosine, 5-Formylcytosine, 5-Carboxylcytosine and 5-Hydroxymethyluracil) and Their Interrelationships
por: Gackowski, Daniel, et al.
Publicado: (2015)

Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence
por: Hashimoto, Hideharu, et al.
Publicado: (2014)

TET-Catalyzed 5-Carboxylcytosine Promotes CTCF Binding to Suboptimal Sequences Genome-wide
por: Nanan, Kyster K., et al.
Publicado: (2019)

Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine
por: Yang, Jie, et al.
Publicado: (2019)

Thymine DNA glycosylase recognizes the geometry alteration of minor grooves induced by 5-formylcytosine and 5-carboxylcytosine
por: Fu, Tianran, et al.
Publicado: (2019)

Enzymatic Hydroxylation and Excision of Extended 5-Methylcytosine Analogues
por: Tomkuvienė, Miglė, et al.
Publicado: (2020)

A comprehensive mechanism for 5-carboxylcytosine-induced transcriptional pausing revealed by Markov state models
por: Konovalov, Kirill A., et al.
Publicado: (2021)

5-Carboxylcytosine is resistant towards phosphodiesterase I digestion: implications for epigenetic modification quantification by mass spectrometry
por: Yuan, Fang, et al.
Publicado: (2019)

A TET Homologue Protein from Coprinopsis cinerea (CcTET) That Biochemically Converts 5-Methylcytosine to 5-Hydroxymethylcytosine, 5-Formylcytosine, and 5-Carboxylcytosine
por: Zhang, Liang, et al.
Publicado: (2014)

DNA repair enzymes ALKBH2, ALKBH3, and AlkB oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in vitro
por: Bian, Ke, et al.
Publicado: (2019)

Differential Stabilities and Sequence-Dependent Base Pair Opening Dynamics of Watson–Crick Base Pairs with 5-Hydroxymethylcytosine, 5-Formylcytosine, or 5-Carboxylcytosine
por: Szulik, Marta W., et al.
Publicado: (2015)

Correction to Differential Stabilities and Sequence-Dependent Base Pair Opening Dynamics of Watson–Crick Base Pairs with 5-Hydroxymethylcytosine, 5-Formylcytosine, or 5-Carboxylcytosine
por: Szulik, Marta W., et al.
Publicado: (2015)

Dynamics of 5-carboxylcytosine during hepatic differentiation: Potential general role for active demethylation by DNA repair in lineage specification
por: Lewis, Lara C., et al.
Publicado: (2017)

Direct decarboxylation of ten-eleven translocation-produced 5-carboxylcytosine in mammalian genomes forms a new mechanism for active DNA demethylation
por: Feng, Yang, et al.
Publicado: (2021)

Dysregulation and prognostic potential of 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) levels in prostate cancer
por: Storebjerg, Tine Maj, et al.
Publicado: (2018)

Evaluation of NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 genes in familial colorectal cancer predisposition
por: Broderick, Peter, et al.
Publicado: (2006)

Evidence for the Involvement of DNA Repair Enzyme NEIL1 in Nucleotide Excision Repair of (5′R)- and (5′S)-8,5′-Cyclo-2′-deoxyadenosines
por: Jaruga, Pawel, et al.
Publicado: (2010)

Systematic analysis of the binding behaviour of UHRF1 towards different methyl- and carboxylcytosine modification patterns at CpG dyads
por: Schneider, Markus, et al.
Publicado: (2020)

Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation
por: Schomacher, Lars, et al.
Publicado: (2016)

TET-mediated oxidation of methylcytosine causes TDG or NEIL glycosylase dependent gene reactivation
por: Müller, Udo, et al.
Publicado: (2014)

Accurate quantification of 5-Methylcytosine, 5-Hydroxymethylcytosine, 5-Formylcytosine, and 5-Carboxylcytosine in genomic DNA from breast cancer by chemical derivatization coupled with ultra performance liquid chromatography- electrospray quadrupole time of flight mass spectrometry analysis
por: Guo, Mengzhe, et al.
Publicado: (2017)

Nei Endonuclease VIII-Like1 (NEIL1) Inhibits Apoptosis of Human Colorectal Cancer Cells
por: Xue, Wanjuan, et al.
Publicado: (2020)

Regulation of NEIL1 protein abundance by RAD9 is important for efficient base excision repair
por: Panigrahi, Sunil K., et al.
Publicado: (2015)

The Human DNA glycosylases NEIL1 and NEIL3 Excise Psoralen-Induced DNA-DNA Cross-Links in a Four-Stranded DNA Structure
por: Martin, Peter R., et al.
Publicado: (2017)

NEIL1 excises 3′ end proximal oxidative DNA lesions resistant to cleavage by NTH1 and OGG1
por: Parsons, Jason L., et al.
Publicado: (2005)

Comparative Nucleosomal Reactivity of 5‐Formyl‐Uridine and 5‐Formyl‐Cytidine
por: Runtsch, Leander Simon, et al.
Publicado: (2021)

Base excision repair of the N-(2-deoxy-d-erythro-pentofuranosyl)-urea lesion by the hNEIL1 glycosylase
por: Tomar, Rachana, et al.
Publicado: (2023)

Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice
por: Skarpengland, Tonje, et al.
Publicado: (2016)

Genome-wide analysis reveals TET-and TDG-mediated 5-methylcytosine oxidation dynamics
por: Shen, Li, et al.
Publicado: (2013)

Genome-wide analysis reveals TET-and TDG-mediated 5-methylcytosine oxidation dynamics
por: Shen, Li, et al.
Publicado: (2013)

Interfering with nucleotide excision by the coronavirus 3’-to-5’ exoribonuclease
por: Chinthapatla, Rukesh, et al.
Publicado: (2022)

Interfering with nucleotide excision by the coronavirus 3′-to-5′ exoribonuclease
por: Chinthapatla, Rukesh, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ilr2k42563hf7qq20g9m0bpgut