Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT(2) receptor reciprocally modulate their signaling functions

Understanding the function of orphan G protein-coupled receptors (GPCRs), whose cognate ligand is unknown, is of major importance as GPCRs are privileged drug targets for many diseases. Recent phylogenetic studies classified three orphan receptors, GPR61, GPR62 and GPR135 among the melatonin recepto...

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Detalles Bibliográficos
Autores principales: Oishi, Atsuro, Karamitri, Angeliki, Gerbier, Romain, Lahuna, Olivier, Ahmad, Raise, Jockers, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566548/
https://www.ncbi.nlm.nih.gov/pubmed/28827538
http://dx.doi.org/10.1038/s41598-017-08996-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566548/
https://www.ncbi.nlm.nih.gov/pubmed/28827538
http://dx.doi.org/10.1038/s41598-017-08996-7

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