Neutralization of Human Interleukin 23 by Multivalent Nanobodies Explained by the Structure of Cytokine–Nanobody Complex

The heterodimeric cytokine interleukin (IL) 23 comprises the IL12-shared p40 subunit and an IL23-specific subunit, p19. Together with IL12 and IL27, IL23 sits at the apex of the regulatory mechanisms shaping adaptive immune responses. IL23, together with IL17, plays an important role in the developm...

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Detalles Bibliográficos
Autores principales: Desmyter, Aline, Spinelli, Silvia, Boutton, Carlo, Saunders, Michael, Blachetot, Christophe, de Haard, Hans, Denecker, Geertrui, Van Roy, Maarten, Cambillau, Christian, Rommelaere, Heidi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566574/
https://www.ncbi.nlm.nih.gov/pubmed/28871249
http://dx.doi.org/10.3389/fimmu.2017.00884

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566574/
https://www.ncbi.nlm.nih.gov/pubmed/28871249
http://dx.doi.org/10.3389/fimmu.2017.00884

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