Clinical Benefit from Trametinib in a Patient with Appendiceal Adenocarcinoma with a GNAS R201H Mutation

We report the case of a patient with appendiceal adenocarcinoma with mucinous peritoneal carcinomatosis who was treated with trametinib upon identification of a GNAS R201H mutation by comprehensive genomic profiling. The molecular pathology of appendiceal neoplasms is reviewed, and the mechanistic b...

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Detalles Bibliográficos
Autores principales: Ang, Celina, Stollman, Aryeh, Zhu, Hongfa, Sarpel, Umut, Scarborough, Bethann, Sahni, Gagan, Millis, Sherri Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567127/
https://www.ncbi.nlm.nih.gov/pubmed/28868010
http://dx.doi.org/10.1159/000477562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567127/
https://www.ncbi.nlm.nih.gov/pubmed/28868010
http://dx.doi.org/10.1159/000477562

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