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Clinical Benefit from Trametinib in a Patient with Appendiceal Adenocarcinoma with a GNAS R201H Mutation
We report the case of a patient with appendiceal adenocarcinoma with mucinous peritoneal carcinomatosis who was treated with trametinib upon identification of a GNAS R201H mutation by comprehensive genomic profiling. The molecular pathology of appendiceal neoplasms is reviewed, and the mechanistic b...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567127/ https://www.ncbi.nlm.nih.gov/pubmed/28868010 http://dx.doi.org/10.1159/000477562 |
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author | Ang, Celina Stollman, Aryeh Zhu, Hongfa Sarpel, Umut Scarborough, Bethann Sahni, Gagan Millis, Sherri Z. |
author_facet | Ang, Celina Stollman, Aryeh Zhu, Hongfa Sarpel, Umut Scarborough, Bethann Sahni, Gagan Millis, Sherri Z. |
author_sort | Ang, Celina |
collection | PubMed |
description | We report the case of a patient with appendiceal adenocarcinoma with mucinous peritoneal carcinomatosis who was treated with trametinib upon identification of a GNAS R201H mutation by comprehensive genomic profiling. The molecular pathology of appendiceal neoplasms is reviewed, and the mechanistic basis underlying the clinical benefit as well as the subsequent course on trametinib that were observed in this patient are discussed. |
format | Online Article Text |
id | pubmed-5567127 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-55671272017-09-01 Clinical Benefit from Trametinib in a Patient with Appendiceal Adenocarcinoma with a GNAS R201H Mutation Ang, Celina Stollman, Aryeh Zhu, Hongfa Sarpel, Umut Scarborough, Bethann Sahni, Gagan Millis, Sherri Z. Case Rep Oncol Case Report We report the case of a patient with appendiceal adenocarcinoma with mucinous peritoneal carcinomatosis who was treated with trametinib upon identification of a GNAS R201H mutation by comprehensive genomic profiling. The molecular pathology of appendiceal neoplasms is reviewed, and the mechanistic basis underlying the clinical benefit as well as the subsequent course on trametinib that were observed in this patient are discussed. S. Karger AG 2017-06-22 /pmc/articles/PMC5567127/ /pubmed/28868010 http://dx.doi.org/10.1159/000477562 Text en Copyright © 2017 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission. |
spellingShingle | Case Report Ang, Celina Stollman, Aryeh Zhu, Hongfa Sarpel, Umut Scarborough, Bethann Sahni, Gagan Millis, Sherri Z. Clinical Benefit from Trametinib in a Patient with Appendiceal Adenocarcinoma with a GNAS R201H Mutation |
title | Clinical Benefit from Trametinib in a Patient with Appendiceal Adenocarcinoma with a GNAS R201H Mutation |
title_full | Clinical Benefit from Trametinib in a Patient with Appendiceal Adenocarcinoma with a GNAS R201H Mutation |
title_fullStr | Clinical Benefit from Trametinib in a Patient with Appendiceal Adenocarcinoma with a GNAS R201H Mutation |
title_full_unstemmed | Clinical Benefit from Trametinib in a Patient with Appendiceal Adenocarcinoma with a GNAS R201H Mutation |
title_short | Clinical Benefit from Trametinib in a Patient with Appendiceal Adenocarcinoma with a GNAS R201H Mutation |
title_sort | clinical benefit from trametinib in a patient with appendiceal adenocarcinoma with a gnas r201h mutation |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567127/ https://www.ncbi.nlm.nih.gov/pubmed/28868010 http://dx.doi.org/10.1159/000477562 |
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