Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages

To examine the pathogenic role of α-synuclein (αS) in Parkinson’s Disease, we have generated induced Pluripotent Stem Cell lines from early onset Parkinson’s Disease patients with SNCA A53T and SNCA Triplication mutations, and in this study have differentiated them to PSC-macrophages (pMac), which r...

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Detalles Bibliográficos
Autores principales: Haenseler, Walther, Zambon, Federico, Lee, Heyne, Vowles, Jane, Rinaldi, Federica, Duggal, Galbha, Houlden, Henry, Gwinn, Katrina, Wray, Selina, Luk, Kelvin C., Wade-Martins, Richard, James, William S., Cowley, Sally A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567139/
https://www.ncbi.nlm.nih.gov/pubmed/28827786
http://dx.doi.org/10.1038/s41598-017-09362-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567139/
https://www.ncbi.nlm.nih.gov/pubmed/28827786
http://dx.doi.org/10.1038/s41598-017-09362-3

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