Opposite feedback from mTORC1 to H-ras and K-ras4B downstream of SREBP1

As a major growth factor transducer, Ras is an upstream activator of mTORC1, which further integrates nutrient and energy inputs. To ensure a contextual coupling of cell division via Ras/MAPK-signalling and growth via mTORC1-signalling, feedback loops from one pathway back to the other are required....

Descripción completa

Detalles Bibliográficos
Autores principales: Posada, Itziar M. D., Lectez, Benoit, Siddiqui, Farid A., Oetken-Lindholm, Christina, Sharma, Mukund, Abankwa, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567141/
https://www.ncbi.nlm.nih.gov/pubmed/28827765
http://dx.doi.org/10.1038/s41598-017-09387-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567141/
https://www.ncbi.nlm.nih.gov/pubmed/28827765
http://dx.doi.org/10.1038/s41598-017-09387-8

Ejemplares similares