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SIRT1 reduction is associated with sex-specific dysregulation of renal lipid metabolism and stress responses in offspring by maternal high-fat diet

Rodent models of maternal obesity have been associated with kidney damage and dysfunction in offspring. However, the underlying mechanisms are yet to be elucidated. In this study, female rats were fed a high-fat diet (HFD) for 6 weeks prior to mating, throughout gestation and lactation; both male an...

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Detalles Bibliográficos
Autores principales: Nguyen, Long The, Chen, Hui, Pollock, Carol, Saad, Sonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567163/
https://www.ncbi.nlm.nih.gov/pubmed/28827681
http://dx.doi.org/10.1038/s41598-017-08694-4