Efficient generation of bispecific IgG antibodies by split intein mediated protein trans-splicing system

Many methods have been developed to produce bispecific antibodies (BsAbs) for industrial application. However, huge challenges still remain in synthesizing whole length BsAbs, including their assembly, stability, immunogenicity, and pharmacodynamics. Here we present for first time a generic technolo...

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Detalles Bibliográficos
Autores principales: Han, Lei, Chen, Junsheng, Ding, Kai, Zong, Huifang, Xie, Yueqing, Jiang, Hua, Zhang, Baohong, Lu, Huili, Yin, Weihan, Gilly, John, Zhu, Jianwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567192/
https://www.ncbi.nlm.nih.gov/pubmed/28827777
http://dx.doi.org/10.1038/s41598-017-08641-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567192/
https://www.ncbi.nlm.nih.gov/pubmed/28827777
http://dx.doi.org/10.1038/s41598-017-08641-3

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