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Efficient generation of bispecific IgG antibodies by split intein mediated protein trans-splicing system
Many methods have been developed to produce bispecific antibodies (BsAbs) for industrial application. However, huge challenges still remain in synthesizing whole length BsAbs, including their assembly, stability, immunogenicity, and pharmacodynamics. Here we present for first time a generic technolo...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567192/ https://www.ncbi.nlm.nih.gov/pubmed/28827777 http://dx.doi.org/10.1038/s41598-017-08641-3 |