Hepatic overproduction of 13-HODE due to ALOX15 upregulation contributes to alcohol-induced liver injury in mice

Chronic alcohol feeding causes lipid accumulation and apoptosis in the liver. This study investigated the role of bioactive lipid metabolites in alcohol-induced liver damage and tested the potential of targeting arachidonate 15-lipoxygenase (ALOX15) in treating alcoholic liver disease (ALD). Results...

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Detalles Bibliográficos
Autores principales: Zhang, Wenliang, Zhong, Wei, Sun, Qian, Sun, Xinguo, Zhou, Zhanxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567196/
https://www.ncbi.nlm.nih.gov/pubmed/28827690
http://dx.doi.org/10.1038/s41598-017-02759-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567196/
https://www.ncbi.nlm.nih.gov/pubmed/28827690
http://dx.doi.org/10.1038/s41598-017-02759-0

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