Cargando…

Hepatic overproduction of 13-HODE due to ALOX15 upregulation contributes to alcohol-induced liver injury in mice

Chronic alcohol feeding causes lipid accumulation and apoptosis in the liver. This study investigated the role of bioactive lipid metabolites in alcohol-induced liver damage and tested the potential of targeting arachidonate 15-lipoxygenase (ALOX15) in treating alcoholic liver disease (ALD). Results...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Wenliang, Zhong, Wei, Sun, Qian, Sun, Xinguo, Zhou, Zhanxiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567196/ https://www.ncbi.nlm.nih.gov/pubmed/28827690 http://dx.doi.org/10.1038/s41598-017-02759-0

Ejemplares similares

Modulation of Intestinal Barrier and Bacterial Endotoxin Production Contributes to the Beneficial Effect of Nicotinic Acid on Alcohol-Induced Endotoxemia and Hepatic Inflammation in Rats
por: Zhong, Wei, et al.
Publicado: (2015)

Adipose-specific lipin1 overexpression in mice protects against alcohol-induced liver injury
por: Zhang, Wenliang, et al.
Publicado: (2018)

Mitochondria-targeted ubiquinone (MitoQ) enhances acetaldehyde clearance by reversing alcohol-induced posttranslational modification of aldehyde dehydrogenase 2: A molecular mechanism of protection against alcoholic liver disease
por: Hao, Liuyi, et al.
Publicado: (2017)

Pinosylvin exacerbates LPS-induced apoptosis via ALOX 15 upregulation in leukocytes
por: Kwon, Ohseong, et al.
Publicado: (2018)

Cytomegalovirus Infection Triggers the Secretion of the PPARγ Agonists 15-Hydroxyeicosatetraenoic Acid (15-HETE) and 13-Hydroxyoctadecadienoic Acid (13-HODE) in Human Cytotrophoblasts and Placental Cultures
por: Leghmar, Kaoutar, et al.
Publicado: (2015)

TLR9 Signaling Protects Alcohol-Induced Hepatic Oxidative Stress but Worsens Liver Inflammation in Mice
por: Hao, Liuyi, et al.
Publicado: (2021)

Alox12/15 Deficiency Exacerbates, While Lipoxin A(4) Ameliorates Hepatic Inflammation in Murine Alcoholic Hepatitis
por: Queck, Alexander, et al.
Publicado: (2020)

Hydroperoxidation of Docosahexaenoic Acid by Human ALOX12 and pigALOX15-mini-LOX
por: Canyelles-Niño, Miquel, et al.
Publicado: (2023)

12/15 lipoxygenase regulation of colorectal tumorigenesis is determined by the relative tumor levels of its metabolite 12-HETE and 13-HODE in animal models
por: Chang, Jian, et al.
Publicado: (2014)

Promoting intestinal antimicrobial defense and microbiome symbiosis contributes to IL-22-mediated protection against alcoholic hepatitis in mice
por: Yue, Ruichao, et al.
Publicado: (2023)

Lipoxins, RevD1 and 9, 13 HODE as the most important derivatives after an early incident of ischemic stroke
por: Szczuko, Małgorzata, et al.
Publicado: (2020)

Conformational Heterogeneity and Cooperative Effects of Mammalian ALOX15
por: Ivanov, Igor, et al.
Publicado: (2021)

Activation of AhR-NQO1 Signaling Pathway Protects Against Alcohol-Induced Liver Injury by Improving Redox Balance
por: Dong, Haibo, et al.
Publicado: (2021)

Level of Potassium Is Associated with Saturated Fatty Acids in Cell Membranes and Influences the Activation of the 9 and 13 HODE and 5 HETE Synthesis Pathways in PCOS
por: Szczuko, Małgorzata, et al.
Publicado: (2022)

Knock-In Mice Expressing a 15-Lipoxygenating Alox5 Mutant Respond Differently to Experimental Inflammation Than Reported Alox5(−/−) Mice
por: Marbach-Breitrück, Eugenia, et al.
Publicado: (2021)

Activation of mTORC1 by Free Fatty Acids Suppresses LAMP2 and Autophagy Function via ER Stress in Alcohol-Related Liver Disease
por: Guo, Wei, et al.
Publicado: (2021)

A review on the relationship between Arachidonic acid 15-Lipoxygenase (ALOX15) and diabetes mellitus
por: He, Kaiying, et al.
Publicado: (2023)

Action mechanism of hypoglycemic principle 9-(R)-HODE isolated from cortex lycii based on a metabolomics approach
por: Liu, Yueqiu, et al.
Publicado: (2022)

WFDC12-overexpressing contributes to the development of atopic dermatitis via accelerating ALOX12/15 metabolism and PAF accumulation
por: Li, Guolin, et al.
Publicado: (2023)

Methylated HNRNPK acts on RPS19 to regulate ALOX15 synthesis in erythropoiesis
por: Naarmann-de Vries, Isabel S, et al.
Publicado: (2021)

Paradoxical Induction of ALOX15/15B by Cortisol in Human Amnion Fibroblasts: Implications for Inflammatory Responses of the Fetal Membranes at Parturition
por: Zhang, Fan, et al.
Publicado: (2023)

Resolution of PMA-Induced Skin Inflammation Involves Interaction of IFN-γ and ALOX15
por: Zhang, Guojun, et al.
Publicado: (2013)

ALOX15-launched PUFA-phospholipids peroxidation increases the susceptibility of ferroptosis in ischemia-induced myocardial damage
por: Ma, Xiao-Hui, et al.
Publicado: (2022)

Meta-Analysis of Mutations in ALOX12B or ALOXE3 Identified in a Large Cohort of 224 Patients
por: Hotz, Alrun, et al.
Publicado: (2021)

Expression of DHA-Metabolizing Enzyme Alox15 is Regulated by Selective Histone Acetylation in Neuroblastoma Cells
por: Ho, Christabel Fung-Yih, et al.
Publicado: (2017)

Deletion of Alox15 improves kidney dysfunction and inhibits fibrosis by increased PGD(2) in the kidney
por: Takahashi, Naohiro, et al.
Publicado: (2021)

Efferocytosis potentiates the expression of arachidonate 15-lipoxygenase (ALOX15) in alternatively activated human macrophages through LXR activation
por: Snodgrass, Ryan G., et al.
Publicado: (2020)

S1PR1/S1PR3-YAP signaling and S1P-ALOX15 signaling contribute to an aggressive behavior in obesity-lymphoma
por: Wang, Xingtong, et al.
Publicado: (2023)

Fatty Acids Inhibit LAMP2-Mediated Autophagy Flux via Activating ER Stress Pathway in Alcohol-Related Liver Disease
por: Guo, Wei, et al.
Publicado: (2021)

An Overproduction of Scholars
Publicado: (1893)

The suppression of cervical cancer ferroptosis by macrophages: The attenuation of ALOX15 in cancer cells by macrophages-derived exosomes
por: Luo, Yanlin, et al.
Publicado: (2023)

Functional Characterization of Transgenic Mice Overexpressing Human 15-Lipoxygenase-1 (ALOX15) under the Control of the aP2 Promoter
por: Heydeck, Dagmar, et al.
Publicado: (2023)

Knock-in mice expressing a humanized arachidonic acid 15-lipoxygenase (Alox15) carry a partly dysfunctional erythropoietic system
por: Reisch, Florian, et al.
Publicado: (2023)

Hepatic SIRT3 Upregulation in Response to Chronic Alcohol Consumption Contributes to Alcoholic Liver Disease in Mice
por: Ma, Yue, et al.
Publicado: (2019)

Shikonin-induced necroptosis in nasopharyngeal carcinoma cells via ROS overproduction and upregulation of RIPK1/RIPK3/MLKL expression
por: Liu, Tiancong, et al.
Publicado: (2019)

Hypermethylation of the ALOX12 and CBS promoters in osteoporosis: Potential biomarkers for early diagnosis
por: Guo, Shang, et al.
Publicado: (2023)

Prandial Hypertriglyceridemia in Metabolic Syndrome Is Due to an Overproduction of Both Chylomicron and VLDL Triacylglycerol
por: Shojaee-Moradie, Fariba, et al.
Publicado: (2013)

Hypoxic cardiac fibroblasts from failing human hearts decrease cardiomyocyte beating frequency in an ALOX15 dependent manner
por: Sandstedt, Mikael, et al.
Publicado: (2018)

Targeting Circulating lncRNA ENST00000538705.1 Relieves Acute Coronary Syndrome via Modulating ALOX15
por: Chen, Hao, et al.
Publicado: (2022)

Functional Characterization of Mouse and Human Arachidonic Acid Lipoxygenase 15B (ALOX15B) Orthologs and of Their Mutants Exhibiting Humanized and Murinized Reaction Specificities
por: Kakularam, Kumar R., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_m1kra4kredee3cjslj5e226jbp