The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation

A major hallmark of Parkinson’s disease (PD) is the presence of Lewy bodies (LBs) in certain neuronal tissues. LBs are protein-rich inclusions, in which α-synuclein (α-syn) is the most abundant protein. Since these inclusions are not present in healthy individuals, despite the high concentration of...

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Detalles Bibliográficos
Autores principales: Aprile, Francesco A., Källstig, Emma, Limorenko, Galina, Vendruscolo, Michele, Ron, David, Hansen, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567236/
https://www.ncbi.nlm.nih.gov/pubmed/28831037
http://dx.doi.org/10.1038/s41598-017-08324-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567236/
https://www.ncbi.nlm.nih.gov/pubmed/28831037
http://dx.doi.org/10.1038/s41598-017-08324-z

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