Hypoxia regulates RhoA and Wnt/β-catenin signaling in a context-dependent way to control re-differentiation of chondrocytes

Cartilage tissue is avascular and hypoxic which regulates chondrocyte phenotype via stabilization of HIFs. Here, we investigated the role of hypoxia and HIFs in regulation of Rho and canonical Wnt signaling in chondrocytes. Our data demonstrates that hypoxia controls the expression of RhoA in chondr...

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Detalles Bibliográficos
Autores principales: Öztürk, Ece, Hobiger, Stefanie, Despot-Slade, Evelin, Pichler, Michael, Zenobi-Wong, Marcy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567364/
https://www.ncbi.nlm.nih.gov/pubmed/28831110
http://dx.doi.org/10.1038/s41598-017-09505-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567364/
https://www.ncbi.nlm.nih.gov/pubmed/28831110
http://dx.doi.org/10.1038/s41598-017-09505-6

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