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Hypoxia regulates RhoA and Wnt/β-catenin signaling in a context-dependent way to control re-differentiation of chondrocytes
Cartilage tissue is avascular and hypoxic which regulates chondrocyte phenotype via stabilization of HIFs. Here, we investigated the role of hypoxia and HIFs in regulation of Rho and canonical Wnt signaling in chondrocytes. Our data demonstrates that hypoxia controls the expression of RhoA in chondr...
Autores principales: | Öztürk, Ece, Hobiger, Stefanie, Despot-Slade, Evelin, Pichler, Michael, Zenobi-Wong, Marcy |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567364/ https://www.ncbi.nlm.nih.gov/pubmed/28831110 http://dx.doi.org/10.1038/s41598-017-09505-6 |
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