Olfactory bulb neuroproteomics reveals a chronological perturbation of survival routes and a disruption of prohibitin complex during Alzheimer’s disease progression

Olfactory dysfunction is among the earliest features of Alzheimer’s disease (AD). Although neuropathological abnormalities have been detected in the olfactory bulb (OB), little is known about its dynamic biology. Here, OB- proteome analysis showed a stage-dependent synaptic proteostasis impairment d...

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Detalles Bibliográficos
Autores principales: Lachén-Montes, Mercedes, González-Morales, Andrea, Zelaya, María Victoria, Pérez-Valderrama, Estela, Ausín, Karina, Ferrer, Isidro, Fernández-Irigoyen, Joaquín, Santamaría, Enrique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567385/
https://www.ncbi.nlm.nih.gov/pubmed/28831118
http://dx.doi.org/10.1038/s41598-017-09481-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567385/
https://www.ncbi.nlm.nih.gov/pubmed/28831118
http://dx.doi.org/10.1038/s41598-017-09481-x

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