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Visualizing multistep elevator-like transitions of a nucleoside transporter

Membrane transporters move substrates across the membrane by alternating access of their binding sites to one side of the membrane at a time. An emerging model is the elevator mechanism in which a substrate-binding transport domain moves a large distance across the membrane. This mechanism has been...

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Detalles Bibliográficos
Autores principales: Hirschi, Marscha, Johnson, Zachary Lee, Lee, Seok-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567992/
https://www.ncbi.nlm.nih.gov/pubmed/28424521
http://dx.doi.org/10.1038/nature22057