Cargando…

Metabolic profiling of triple-negative breast cancer cells reveals metabolic vulnerabilities

BACKGROUND: Among breast cancers, the triple-negative breast cancer (TNBC) subtype has the worst prognosis with no approved targeted therapies and only standard chemotherapy as the backbone of systemic therapy. Unique metabolic changes in cancer progression provide innovative therapeutic opportuniti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lanning, Nathan J., Castle, Joshua P., Singh, Simar J., Leon, Andre N., Tovar, Elizabeth A., Sanghera, Amandeep, MacKeigan, Jeffrey P., Filipp, Fabian V., Graveel, Carrie R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568171/ https://www.ncbi.nlm.nih.gov/pubmed/28852500 http://dx.doi.org/10.1186/s40170-017-0168-x

Ejemplares similares

Unique Metabolic Contexts Sensitize Cancer Cells and Discriminate between Glycolytic Tumor Types
por: Chacon-Barahona, Jonathan A., et al.
Publicado: (2023)

Mitochondria in cancer: at the crossroads of life and death
por: Fogg, Vanessa C., et al.
Publicado: (2011)

Downregulation of the Mitochondrial Phosphatase PTPMT1 Is Sufficient to Promote Cancer Cell Death
por: Niemi, Natalie M., et al.
Publicado: (2013)

DDK Promotes Tumor Chemoresistance and Survival via Multiple Pathways
por: Sasi, Nanda Kumar, et al.
Publicado: (2017)

The Pseudophosphatase MK-STYX Physically and Genetically Interacts with the Mitochondrial Phosphatase PTPMT1
por: Niemi, Natalie M., et al.
Publicado: (2014)

Leaving the lysosome behind: novel developments in autophagy inhibition
por: Solitro, Abigail R, et al.
Publicado: (2016)

Correction: Cytokine Receptor-Like Factor 1 (CRLF1) Protects against 6-Hydroxydopamine Toxicity Independent of the gp130/JAK Signaling Pathway
por: Looyenga, Brendan D., et al.
Publicado: (2014)

Cytokine Receptor-Like Factor 1 (CRLF1) Protects against 6-Hydroxydopamine Toxicity Independent of the gp130/JAK Signaling Pathway
por: Looyenga, Brendan D., et al.
Publicado: (2013)

Oxidative Phosphorylation Is a Metabolic Vulnerability in Chemotherapy-Resistant Triple-Negative Breast Cancer
por: Evans, Kurt W., et al.
Publicado: (2021)

Targeting MET and EGFR crosstalk signaling in triple-negative breast cancers
por: Linklater, Erik S., et al.
Publicado: (2016)

Quantitation of Tissue Amyloid via Fluorescence Spectroscopy Using Controlled Concentrations of Thioflavin-S
por: MacKeigan, Tatiana P., et al.
Publicado: (2023)

Glycogen synthase 1 targeting reveals a metabolic vulnerability in triple-negative breast cancer
por: de Heer, E. C., et al.
Publicado: (2023)

Metabolic shift in density-dependent stem cell differentiation
por: Singh, Simar J., et al.
Publicado: (2017)

Correction: Glycogen synthase 1 targeting reveals a metabolic vulnerability in triple-negative breast cancer
por: de Heer, E. C., et al.
Publicado: (2023)

Omics Analysis of Chemoresistant Triple Negative Breast Cancer Cells Reveals Novel Metabolic Vulnerabilities
por: Kordias, Dimitris, et al.
Publicado: (2022)

Persistent Mitochondrial Hyperfusion Promotes G2/M Accumulation and Caspase-Dependent Cell Death
por: Westrate, Laura M., et al.
Publicado: (2014)

Computational Analysis of an Autophagy/Translation Switch Based on Mutual Inhibition of MTORC1 and ULK1
por: Szymańska, Paulina, et al.
Publicado: (2015)

STAT3 Is Activated by JAK2 Independent of Key Oncogenic Driver Mutations in Non-Small Cell Lung Carcinoma
por: Looyenga, Brendan D., et al.
Publicado: (2012)

Chemical Biology Screening Identifies a Vulnerability to Checkpoint Kinase Inhibitors in TSC2-Deficient Renal Angiomyolipomas
por: Vaughan, Robert M., et al.
Publicado: (2022)

PI3K-C2α knockdown decreases autophagy and maturation of endocytic vesicles
por: Merrill, Nathan M., et al.
Publicado: (2017)

Mitochondrial Morphological Features Are Associated with Fission and Fusion Events
por: Westrate, Laura M., et al.
Publicado: (2014)

Metabolic characterization of triple negative breast cancer
por: Cao, Maria D, et al.
Publicado: (2014)

Metabolic Reprogramming in Triple-Negative Breast Cancer
por: Sun, Xiangyu, et al.
Publicado: (2020)

Metabolic reprogramming in triple-negative breast cancer
por: Wang, Zhanyu, et al.
Publicado: (2020)

DDK Has a Primary Role in Processing Stalled Replication Forks to Initiate Downstream Checkpoint Signaling
por: Sasi, Nanda Kumar, et al.
Publicado: (2018)

Metabolic Response of Triple-Negative Breast Cancer to Folate Restriction
por: Coleman, Michael F., et al.
Publicado: (2021)

Cancer metabolism meets systems biology: Pyruvate kinase isoform PKM2 is a metabolic master regulator
por: Filipp, Fabian V.
Publicado: (2013)

Metformin Targets Glucose Metabolism in Triple Negative Breast Cancer
por: Wahdan-Alaswad, RS, et al.
Publicado: (2018)

Systems biology analysis of mitogen activated protein kinase inhibitor resistance in malignant melanoma
por: Zecena, Helma, et al.
Publicado: (2018)

Computational model for autophagic vesicle dynamics in single cells
por: Martin, Katie R., et al.
Publicado: (2013)

Identification of Small Molecule Inhibitors of PTPσ through an Integrative Virtual and Biochemical Approach
por: Martin, Katie R., et al.
Publicado: (2012)

Metabolic Syndrome and Triple-Negative Breast Cancer: A New Paradigm
por: Davis, Andrew A., et al.
Publicado: (2012)

Key Players in Choline Metabolic Reprograming in Triple-Negative Breast Cancer
por: Iorio, Egidio, et al.
Publicado: (2016)

Moderate Exercise Modulates Tumor Metabolism of Triple-Negative Breast Cancer
por: Vulczak, Anderson, et al.
Publicado: (2020)

NPC1 Confers Metabolic Flexibility in Triple Negative Breast Cancer
por: O’Neill, Kathleen I., et al.
Publicado: (2022)

Therapeutic Potential of Tumor Metabolic Reprogramming in Triple-Negative Breast Cancer
por: Munkácsy, Gyöngyi, et al.
Publicado: (2023)

Targeting Metabolic Remodeling in Triple Negative Breast Cancer in a Murine Model
por: García-Castillo, Verónica, et al.
Publicado: (2017)

Metabolic profiles of triple-negative and luminal A breast cancer subtypes in African-American identify key metabolic differences
por: Tayyari, Fariba, et al.
Publicado: (2018)

Vulnerability of Triple-Negative Breast Cancer to Saponin Formosanin C-Induced Ferroptosis
por: Chen, Hsin-Chih, et al.
Publicado: (2022)

Kinome Profiling of NF1-Related MPNSTs in Response to Kinase Inhibition and Doxorubicin Reveals Therapeutic Vulnerabilities
por: Grit, Jamie L., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_1tc0gb65gq85650a89bqjlleiv