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Destabilizing polymorphism in cervid prion protein hydrophobic core determines prion conformation and conversion efficiency
Prion diseases are infectious neurodegenerative disorders of humans and animals caused by misfolded forms of the cellular prion protein PrP(C). Prions cause disease by converting PrP(C) into aggregation-prone PrP(Sc). Chronic wasting disease (CWD) is the most contagious prion disease with substantia...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568445/ https://www.ncbi.nlm.nih.gov/pubmed/28800624 http://dx.doi.org/10.1371/journal.ppat.1006553 |