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Increased Cathepsin S in Prdm1−/− dendritic cells alters T(FH) repertoire and contributes to lupus
Aberrant expansion of follicular helper T (T(FH)) cells occurs in lupus patients. An unanswered question is whether an altered T cell receptor (TCR) repertoire is associated with this expansion. Here, we demonstrate that Blimp-1 repressed expression of the cathepsin S gene (Ctss) which encodes a cys...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568473/ https://www.ncbi.nlm.nih.gov/pubmed/28692065 http://dx.doi.org/10.1038/ni.3793 |