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Increased Cathepsin S in Prdm1−/− dendritic cells alters T(FH) repertoire and contributes to lupus

Aberrant expansion of follicular helper T (T(FH)) cells occurs in lupus patients. An unanswered question is whether an altered T cell receptor (TCR) repertoire is associated with this expansion. Here, we demonstrate that Blimp-1 repressed expression of the cathepsin S gene (Ctss) which encodes a cys...

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Detalles Bibliográficos
Autores principales:	Kim, Sun Jung, Schätzle, Sebastian, Ahmed, S. Sohail, Haap, Wolfgang, Jang, Su-Hwa, Gregersen, Peter K., Georgiou, George, Diamond, Betty
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568473/ https://www.ncbi.nlm.nih.gov/pubmed/28692065 http://dx.doi.org/10.1038/ni.3793

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