Neuropilin 1 sequestration by neuropathogenic mutant glycyl-tRNA synthetase is permissive to vascular homeostasis

The mechanism by which dominantly inherited mutations in the housekeeping gene GARS, which encodes glycyl-tRNA synthetase (GlyRS), mediate selective peripheral nerve toxicity resulting in Charcot-Marie-Tooth disease type 2D (CMT2D) is still largely unresolved. The transmembrane receptor protein neur...

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Detalles Bibliográficos
Autores principales: Sleigh, James N., Gómez-Martín, Adriana, Wei, Na, Bai, Ge, Yang, Xiang-Lei, Schiavo, Giampietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569042/
https://www.ncbi.nlm.nih.gov/pubmed/28835631
http://dx.doi.org/10.1038/s41598-017-10005-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569042/
https://www.ncbi.nlm.nih.gov/pubmed/28835631
http://dx.doi.org/10.1038/s41598-017-10005-w

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