Aspirin metabolite sodium salicylate selectively inhibits transcriptional activity of ATF6α and downstream target genes

In response to ER stress, activating transcription factor 6 (ATF6) traffics from ER to Golgi apparatus where it is activated by cleavage before being translocated as transcription factor to the cell nucleus. In this work we describe ATF6α as a newly target of the aspirin metabolite sodium salicylate...

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Detalles Bibliográficos
Autores principales: Mügge, Fernanda L. B., Silva, Aristóbolo M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569067/
https://www.ncbi.nlm.nih.gov/pubmed/28835710
http://dx.doi.org/10.1038/s41598-017-09500-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569067/
https://www.ncbi.nlm.nih.gov/pubmed/28835710
http://dx.doi.org/10.1038/s41598-017-09500-x

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