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Aspirin metabolite sodium salicylate selectively inhibits transcriptional activity of ATF6α and downstream target genes
In response to ER stress, activating transcription factor 6 (ATF6) traffics from ER to Golgi apparatus where it is activated by cleavage before being translocated as transcription factor to the cell nucleus. In this work we describe ATF6α as a newly target of the aspirin metabolite sodium salicylate...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569067/ https://www.ncbi.nlm.nih.gov/pubmed/28835710 http://dx.doi.org/10.1038/s41598-017-09500-x |